Question
All can cause release of histamine except‑
| A. |
D-TC |
| B. |
Morphine |
| C. |
Propranolol |
| D. |
Vancomycin |
Show Answer
|
Correct Answer » C Explanation |
 |
A. D-tubocurarine
- Can cause histamine release.
- D-tubocurarine is a non-depolarizing neuromuscular blocking agent.
- It is associated with significant histamine release, producing:
- Hypotension
- Flushing
- Tachycardia
- It is considered the maximum histamine-releasing muscle relaxant in the provided material.
B. Morphine
- Can cause histamine release.
- Morphine can produce urticaria, flushing and hypotension through histamine release.
- Histamine-mediated effects are not reversed by naloxone.
C. Propranolol
- Correct answer.
- Propranolol is a non-selective beta-adrenergic blocker.
- It is not listed among drugs causing histamine release in the provided source.
- Therefore, it is the exception.
D. Vancomycin
- Can cause histamine release.
- Rapid intravenous infusion can cause red man/red neck syndrome.
- This occurs due to histamine release, producing diffuse flushing.