Question
| A. |
Seizures in severe pre-eclampsia |
| B. |
Recurrent seizures in eclampsia |
| C. |
Respiratory Distress Syndrome (RDS) in a premature baby |
| D. |
Tachycardia |
|
Correct Answer » C Explanation |
 |
Magnesium sulfate (MgSO₄) is used mainly in obstetrics & cardiology for seizure prevention & certain arrhythmias.
Established uses:
– Prevent seizures in severe pre-eclampsia
– Treat & prevent recurrent seizures in eclampsia
– Treat arrhythmias like torsades de pointes
– Provide fetal neuroprotection in preterm labor (reduces cerebral palsy risk)
Mechanism:
• CNS depressant
• Reduces acetylcholine release
• Stabilizes neuromuscular junction
MgSO₄ toxicity signs:
1. Loss of deep tendon reflexes
2. Respiratory depression
3. Cardiac arrest
Antidote: Calcium gluconate
MgSO₄ *does NOT* prevent Respiratory Distress Syndrome (RDS).
RDS prevention uses antenatal corticosteroids (betamethasone or dexamethasone).
MgSO₄ is given for neuroprotection, not RDS prevention.