Question
| A. |
Nuclear palisading |
| B. |
Keratin pearls |
| C. |
Foamy cells |
| D. |
Psammoma bodies |
|
Correct Answer � A Explanation |
 |
Ans.A. Nuclear palisading
Histologic features of Basal cell carcinoma –
· The tumour cells resemble those in the normal basal layer of the epidermis.
· They arise from the epidermis or the follicular epithelium and do not occur on mucosal surfaces.
· Two patterns are seen: multifocal growths originating from the epidermis and extending over several square centimetres or more of the skin surface (multifocal superficial type) and nodular lesions growing downward deeply into the dermis as cords and islands of variably basophilic cells with hyperchromatic nuclei, embedded in a mucinous matrix and often surrounded
by fibroblasts and lymphocytes.
· The cells forming the periphery of the tumour cell islands tend to be arranged radially with their long axes in approximately parallel arrangement (nuclear palisading).
· The stroma shrinks away from the epithelial tumour nests, creating clefts or separation artefacts that assist in differentiating
basal cell carcinomas from certain appendage tumours also characterized by proliferation of basaloid cells (e.g.
trichoepithelioma).
Option (B): Keratin pearls– Squamous cell carcinoma.
Option (C): Foamy cells – Leprosy.
Option (D): Psammoma bodies– Papillary carcinoma thyroid, Serous cystadenoma ovary, Meningioma.