Question
Which of the following drugs is used for the long term management of obesity
| A. |
Sibutramine |
| B. |
Fenfluramine |
| C. |
Metformin |
| D. |
Liraglutide |
Show Answer
|
Correct Answer » D Explanation |
|
Liraglutide is a GLP-1 (Glucagon-Like Peptide-1) receptor agonist.
Mechanism:
-
↑ Satiety (acts on hypothalamus)
-
↓ Appetite
-
Delays gastric emptying
Indication:
-
Chronic weight management
-
BMI ≥30 kg/m²
-
BMI ≥27 kg/m² with comorbidities
Brand used for obesity: Saxenda
Why Other Options Are Wrong
A. Sibutramine
-
Serotonin–norepinephrine reuptake inhibitor
-
Withdrawn worldwide
-
Causes cardiovascular events
B. Fenfluramine
-
Serotonin releasing drug
-
Withdrawn due to valvular heart disease & pulmonary hypertension
C. Metformin
-
Used for Type 2 diabetes
-
Causes mild weight loss but not approved for obesity treatment
