MCQ – 93248

Correct Answer » B Explanation

B is acini. The acini are the functional units of the exocrine pancreas responsible for producing and secreting digestive enzymes into the pancreatic ducts.

In cystic fibrosis, a genetic disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, there is a defect in the production or function of the CFTR protein.

This leads to thick, sticky mucus forming in various organs, including the pancreas.

In the pancreas, the defective CFTR protein affects the secretion of chloride ions and water, dehydrating pancreatic secretions.

This thickened mucus obstructs the pancreatic ducts, preventing the proper flow of digestive enzymes from the acini into the duodenum. Consequently, there is a reduction in the production and release of pancreatic enzymes, leading to impaired digestion and malabsorption of nutrients.

The Other Options:

A. Islets of Langerhans: The islets of Langerhans are responsible for the production and secretion of hormones such as insulin and glucagon. In cystic fibrosis, the islets are generally not affected, and the primary pancreatic pathology lies in the exocrine portion.

C. Intralobular Duct: The intralobular ducts are part of the pancreatic duct system and play a role in transporting pancreatic enzymes. While cystic fibrosis can cause ductal abnormalities and obstruction, the acini are the primary site of damage and dysfunction.

D. Interlobular Duct: Similar to the intralobular ducts, the interlobular ducts transport pancreatic secretions. However, they are not the main focus of damage in cystic fibrosis-related pancreatic dysfunction.