Menetrier’s Disease
MENETRIER’S DISEASE
- Menetrier’s disease is an unusual condition characterised by hypertrophy of the gastric mucosal folds, mucus production & hypochohydria.
- It is a premalignant condition.
- The mucosal folds inMenetrier’s disease are often most prominent in the body and fundus.
Etiology-
- Caused by excessive secretion of TGF α.
Clinical features-
- Hypoproteinaemia
- Anaemia
- Increased risk of gastric adenocarcinoma associated with protein losing enteropathy.
- May get confused with Zollinger- Ellison syndrome.
- gastropathy accompanied by hypoalbuminemia and edema
Investigations-
Large gastric folds are readily detectable by either radiographic (barium meal) or endoscopic methods
A nondiagnostic biopsy may lead to a surgically obtained full-thickness biopsy to exclude malignancy.
Treatment-
- Gastrectomy.
- Medical therapy vith anticholinergic agents, prostgglandins, PPIs, prednkone, and H, receptor nntagonists
Exam Important
- Menetrier’s disease is an unusual condition characterised by hypertrophy of the gastric mucosal folds, mucus production & hypochohydria.
Etiology-
- Caused by excessive secretion of TGF α.
Clinical Features-
- Increased risk of gastric adenocarcinoma associated with protein losing enteropathy.
- May get confused with Zollinger- Ellison syndrome.
Don’t Forget to Solve all the previous Year Question asked on Menetrier’s Disease
Click Here to Start Quiz
Click Here to Start Quiz
