MORPHOLOGICAL FEATURES OF AMYLOIDOSIS OF ORGANS

1. Amyloidosis of kidneys-

• It is the most common & most serious feature of renal disease.
• Deposits in the kidney mostly in secondary amyloidosis.
• Amyloidosis deposition occurs primarily in glomeruli.
• Glomerulus develops focal deposits within mesengial matrix & diffuses the basement membranes of capillary loops.
• It results in proteinuria & nephrotic syndrome.

2. Amyloidosis of spleen-

• It has 2 patterns-

a) Sago pattern-

• Cut surface shows characteristics tapioca- like granules (sago spleen).

b) Lardaceous spleen-

• Amyloidosis involving splenic sinuses, extending to splenic pulp with formation of large, sheet like deposits.

3. Amyloidosis of Liver-

• It may cause mastium enlargement.
• Histologically, amyloid deposits first appear in the space of Disse.
• Normal liver function is usually preserved.

4. Amyloidosis of Heart-

• It may produce arrhythmias due to deposition in conduction system.
• Amyloid first deposits in subendocardial areas of atrium.
• Most common cause of death is cardiac failure.
• AL amyloid binds & inactivates factor X causes bleeding disorder.