Regulation & Factors of Heme Synthesis
REGULATION & FACTORS OF HEME SYNTHESIS
- ALA synthase is the key regulatory enzyme in hepatic biosynthesis of Heme.
- ALA synthase occurs in hepatic and erythrocytes.
Factors That Heme Synthesis-
- Drugs- Barbiturates, Griseofulvin.
- Lead– inhibits catalyzed by ALA dehydratase and ferrochelatase.
- INH– decreases PLP.
- Intracellular buffer due to histidine residue.The NH2 group on intermediate histidine residues.
Exam Important
- ALA synthase is the key regulatory enzyme in hepatic biosynthesis of Heme.
- ALA synthase occurs in hepatic and erythrocytes.
Factors That Heme Synthesis-
- Drugs- Barbiturates, Griseofulvin.
- Lead– inhibits catalyzed by ALA dehydratase and ferrochelatase.
- INH– decreases PLP.
- Intracellular buffer due to histidine residue.The NH2 group on intermediate histidine residues.
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