Short Quiz on Testicular Tumours
Instruction
2. There is 1 Mark for each correct Answer
Which among the following are Testicular tumour markers?
Three serum tumor markers have established roles in the management of men with testicular germ cell tumors:
Ans. is ‘d’ i.e., CEA
Biological markers of germ cell testicular tumors include AFP, HC Placental alkaline phosphatase, placental lactogen and LDH. HCG , AFP and LDH are widely used clinically and have proved to be valuable in the diagnosis and management of testicular cancer.
Regarding testicular tumour, the following are false except –
Ans is ‘b’ i.e. Seminomas are radio sensitive
Seminomas are well known to be one of the most radiosensitive tumors
About other options
- Option (a) : Commonest malignancy in older males is —> Prostate cancer
- Option (c) : Stage I Nonseminomas (including teratomas) are t/t by surgery alone and show a high cure rate (>95%)
[Stage I seminomas are t/t by surgery + retroperitoneal radiotherapy and show —98% cure rate]
- Option (d) : Chemotherapy shows a good response in advance stage testicular tumors.
Ans. Two options are correct i.e., `b & c’
Testicular tumour can simulate ‑
Ans. is ‘b’ i.e., Scrotum
Testicular tumour most sensitive to radiation is‑
Ans. is ‘d’ i.e., Seminoma
Testicular seminoma is the germ cell tumor, which is very sensitive to radiation therapy.
All of the following testicular tumours are germ cell tumours EXCEPT:
March 2013 (b)
Ans. D i.e. Sertoli cell tumour
Testicular carcinoma
- Bilateral in 10% of cases,
- Abdominal cryptorchid testes are at higher risk as compared to inguinal cryptorchid testes
- Testicular feminization syndrome increases the risk of testicular germ cell tumour
- MC Ca of testes in young: Seminoma
- MC Ca in elderly: Lymphoma
- MC Ca in infants: Yolk sac tumour
Seminoma
- Radiosensitive,
- Corresponds to dysgerminoma of ovary &
- Treatment of choice is: Surgery
Germ Cell Tumors
- Precursor lesion
- Intratubular germ cell neoplasm, unclassified
- Intratubular germ cell neoplasm, specific type
- Tumors of 1 histologic type
- Seminoma
- Variant: Seminoma with syncytiotrophoblastic cells
- Partially regressed tumor showing seminoma with scar
- Spermatocytic seminomaEmbryonal carcinoma
- Variant: Spermatocytic seminoma with a sarcomatous component
- Yolk sac tumor
- ChoriocarcinomaPlacental site trophoblastic tumor
- Variant: “Monophasic” type
- Trophoblastic tumor, unclassified
- Teratoma
- With a secondary somatic type malignant component
- Monodermal variants
- Carcinoid
- Primitive neuroectodermal tumor
- Others
- Seminoma
March 2009
Ans. C: Seminoma
Peak incidence for teratomas is 20-35 years and for seminomas is 35-45 years Seminoma is rare before puberty.
Testicular tumour which responds best to radiation is:
Ans. Seminoma
If a patient has been diagnosed with seminoma, a common form of testicular cancer, it’s very likely he/she will make a full recovery.
This type of cancer, which originates in germ cells in the testicles (also called pure, or classical, seminoma) usually responds well to radiation therapy.
True regarding testicular tumour:
Answer- B,For stage I seminoma- orchidectomy + radiotherapy used for treatment D,Staging is important for planning management E,i3HCG & AFP may be used as marker the response of treatment
Testicular Tumour: Staging
- Stage I: The tumour is confined to the testis;
- Stage II: Nodal disease is present but is confined nodes below the diaphragm;
- Stage III: Nodal disease is present above the diaphragm;
- Stage IV: Nonlymphatic metastatic dise
- In confirmed cases, staging is an essential step in planning treatment.
- HCG & NSGCTs when raised, these markers are used to monitor the response to treatment.
