HUMAN IMMUNOGLOBULINS CLASSES
HUMAN IMMUNOGLOBULINS CLASSES:
Isotype:
- Immunoglobulin isotype class switching is determined by Constant region of heavy chain
- Refers to a particular constant region of the light or heavy chain
- Shared by all members of the same species
- Classes of Ig are differentiated on the basis of isotypic markers on H chains IgG, IgA, IgM, IgD, Ig.
Allotypes
- Refers to allelic differences in both the variable and constant regions of Ig
- Individual specific determinants within a species
- Present in some but not all members of a species
Idiotypes
- Found in the hypervariable region of the Fab portion
- Specific for each antibody molecule
- Class specific antigenic determinants of an immunoglobulin is associated with H-chain
Important points related to various Ig
| Sedimentation coefficient |
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| Molecular weight |
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Serum concentration
Half life Daily production |
G > A > M > D > E
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| Intravascular concentration |
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| Carbohydrate Percentage |
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| Heat labile |
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| Presence in milk |
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| Selective secretion by seromucinous gland |
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| Placental transport |
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Exam Important
HUMAN IMMUNOGLOBULINS CLASSES:
Isotype:
- Immunoglobulin isotype class switching is determined by Constant region of heavy chain
Idiotypes
- Found in the hypervariable region of the Fab portion
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