Human Immunoglobulins Classes

HUMAN IMMUNOGLOBULINS CLASSES:

Isotype:

• Immunoglobulin isotype class switching is determined by Constant region of heavy chain
• Refers to a particular constant region of the light or heavy chain
• Shared by all members of the same species
• Classes of Ig are differentiated on the basis of isotypic markers on H chains IgG, IgA, IgM, IgD, Ig.

Allotypes

• Refers to allelic differences in both the variable and constant regions of Ig
• Individual specific determinants within a species
• Present in some but not all members of a species

Idiotypes

• Found in the hypervariable region of the Fab portion
• Specific for each antibody molecule

Sedimentation coefficient	Max  IgM
Molecular weight	Max IgM Min IgG
Serum concentration Half life Daily production	G > A > M > D > E
Intravascular concentration	Max IgM Min IgA
Carbohydrate Percentage	Max IgM Min IgA
Heat labile	IgB
Presence in milk	IgA IgG
Selective secretion by seromucinous gland	IgA
Placental transport	IgG

HUMAN IMMUNOGLOBULINS CLASSES:

Isotype:

• Immunoglobulin isotype class switching is determined by Constant region of heavy chain

Idiotypes

• Found in the hypervariable region of the Fab portion

Don’t Forget to Solve all the previous Year Question asked on Human Immunoglobulins Classes