Lymphogranuloma Venerum

Ans. is ‘c’ i.e., Cell culture 

. “Cell culture is the preferred mode of isolation now. Many cell lines are susceptible but those commonly used are McCoy and HeLa cells”.

Ans. is ‘a’ i.e., Chlamydia trachomatis 

Five classical STDs are syphilis (T. pallidum), gonorrhoea (N. gonorrhoeae), chanchroid (H. ducreyi), lymphogranuloma venerum (chlamydia trachomatis), and donovanosis (calymmatobacterium gtanulomatosis).

Painless Papule that often go unnoticed. Sometimes it may ulcerate After the genital lesion has healed , painful matted, suppurative lymphadenopathy

A i.e. Chlamydia trachomatis 

C i.e. LGV

C i.e. LGV

C i.e. LGV

C i.e. LGV

B i.e. LGV

A i.e. Doxycycline

Ans. is ‘a’ i.e. Tuberculosis & ‘c’ i.e. LGV 

• A fistula-in-ano, or anal fistula, is a chronic abnormal communication, usually lined to some degree by granulation tissue, which runs outwards from the anorectal opening (the internal opening) to an external opening on the skin of the perineum or buttock (or rarely, in women, to the vagina).
• Anal fistulae may be found in association with specific conditions, such as Crohn’s disease, tuberculosis, lymphogranuloma venereum, actinomycosis, rectal duplication, foreign body, and malignancy.

Ans. A: Tetracycline

The hallmark of LGV is unilateral or bilateral tender lymphadenopathy that dramatically evolves 2 to 6 weeks after the primary lesion.

The involved lymph nodes increase rapidly in size, and pain and erythema are common. If adjacent to one another, several involved lymph nodes may coalesce. The central areas of such lymph nodes can then undergo necrosis. Fluctuant and suppurative lymph nodes then develop, causing the classic ‘bubo’ of LGV.

The bubo may then rupture and drain purulent material, which is associated with relief from symptoms. The ‘groove sign’ characteristic of LGV is seen if both the inguinal and the femoral nodes are involved.

Tetracycline is the first choice drugs for LGV.

Apart from LGV, tetracyclines are drug of choice for:

• STDs-Chlamydial non-specific urethritis/endocervicitis, granuloma inguinale
• Atypical pneumonia
• Cholera
• Brucellosis
• Plague
• Relapsing fever
• Rickettsial infections-typhus, rocky mountain spotted fever, Q fever etc.

Ans. is ‘b’ i.e., Chlamydia trachomatis

• Lymphogranuloma venereum (LGV) is a long-term (chronic) infection of the lymphatic system. 

• It is caused by any of 3 different types (serovars) of the bacteria Chlamydia trachomatis.

• The bacteria are spread by sexual contact. The infection is not caused by the same bacteria that cause genital chlamydia.

• Chlamydia trachomatis causes eye (conjunctivitis, trachoma), respiratory (pneumonia), and genital tract (urethritis, lymphogranuloma venereum) infections. 

• Diagnosis made with nucleic acid test for C trachomatis, LGV serovars diagnosed serologically.

Ans. is ‘a’ i.e., LGV

• Groove sign of Greenblatt’ is pathognomonic of LGV when inguinal lymph nodes are enlarged, they are separated by Poupart’s ligment, producing a groove.