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MCQ – 48824

amit18289

Question

Which of the following methods is NOT used for the measurement of body fluid volumes:
A.

Antipyrine for total body water
B.

Inulin for extracellular fluid
C.

Evans blue for plasma volume
D.

125I-albumin for blood volume
Show Answer

Correct Answer � D

Explanation

Ans. D i.e. 125I-albumin for blood volume

  • Blood cell volume is determined by the hematocrit value and radioisotope method (mainly Cr52).The isotopes most commonly used are chromium. -51 (labelled red blood cells) and iodine-131 (serum albumin), both γ-emitting isotopes.

MEASUREMENT OF BODY FLUID COMPARTMENTS

  •  Measurement of body fluid volumes is done by ‘Dilution method’
VOLUME MEASUREMENT
TBW
  • Heavy water (Deuterium oxide), Tritium oxide, Aminopyrine.
  • By dilution principle
ECF
  • By inulin (most accurate), Sucrose, Mannitol, radioactive sodium, radioactive iodide, Thiosulfate
PLASMA VOLUME(PV)
  • By using Evans blue (T1824), Serum albumin labeled with radioactive Iodine
RED CELL VOLUME
  • By RBCs tagged with radioactive Chromium -51, Phosphorus-32, Fe-55 or Fe59
ICF
  • Can’t be measured directly.
  • Formula = (TBW-ECF)
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