Question
A 48-year-old man is referred to an endocrinologist for newly diagnosed diabetes. He had elevated fasting serum glucose level a week earlier. The endocrinologist discusses the different treatment options available, including oral and injectable medications. He recommends treatment with an oral medication that alters glucose metabolism within the liver and explains that the liver is an important site for glucose regulation. Liver cells that shows high concentration of fructose 2,6-bisphosphate will have a low rate of conversion involving which of the following:
| A. |
Acetyl CoA → Fatty acids |
| B. |
Glucose → glycogen |
| C. |
Alanine → glucose |
| D. |
α-Ketoglutarate → glutamate |
Show Answer
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Correct Answer � C Explanation |
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Ans. C. Alanine → glucose
Fructose 2,6-bisphosphate activates glycolysis by inducing phosphofructokinase-1 and inhibits gluconeogenesis by inhibiting fructose-1,6-bisphosphatase. High concentrations of fructose 2,6-bisphosphate also decreases the gluconeogenic conversion of alanine to glucose. Fructose 2,6-bisphosphate concentration is regulated by a bifunctional enzyme composed of phosphofructokinase-2 and fructose-2,6-bisphosphatase.