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MCQ – 91940

Question

An 18-year-old boy presents with fever, localized bone pain, tenderness, and warmth over the affected area. Laboratory investigations reveal elevated ESR and CRP. A plain radiograph shows a lytic lesion with periosteal reaction described as an “onion-skin” appearance. What is the most likely diagnosis?
A.

Ewing’s sarcoma

B.

Osteosarcoma

C.

Osteomyelitis

D.

Giant cell tumor

Show Answer

Correct Answer » A

Explanation

– Ewing’s sarcoma typically affects children & adolescents (10–20 years).
– Symptoms include fever, localized bone pain, swelling, & systemic signs.
– Lab findings: ↑ ESR & CRP, and sometimes leukocytosis.
– X-ray: “Onion-skin” periosteal reaction & diaphyseal location in long bones (e.g., femur, tibia).
– Often shows an associated soft tissue mass.

Incorrect Options:

– Osteosarcoma: Bone pain & swelling, but fever rare. X-ray shows “sunburst” pattern or Codman’s triangle; occurs in metaphysis.
– Osteomyelitis: Fever, pain, ↑ ESR/CRP; X-ray: irregular lytic lesions & sequestrum, no “onion-skin.” Confirmed by positive cultures/biopsy.
– Giant Cell Tumor: Occurs in 20–40 years; lytic lesion in epiphysis, extending to articular surface; lacks fever/systemic signs.

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