Question
Which of the following ‘rare vaccine reactions’ are known to occur with BCG vaccine?
- Suppurative lymphadenitis
- Guillain-Barré syndrome
- Osteitis
- Disseminated infection
| A. |
1, 2 and 3 |
| B. |
1, 2 and 4 |
| C. |
1, 3 and 4 |
| D. |
2, 3 and 4 |
Show Answer
|
Correct Answer » C Explanation |
 |
1. Suppurative lymphadenitis — Correct
- A recognized rare complication of BCG vaccination.
- Usually involves the regional lymph nodes.
- May progress to suppuration and sinus formation.
2. Guillain–Barré syndrome — Incorrect
- Guillain–Barré syndrome is not a characteristic adverse reaction of BCG.
- It is classically associated with influenza vaccination in vaccine-related MCQs.
3. Osteitis/osteomyelitis — Correct
- BCG can rarely cause osteitis or osteomyelitis.
- It is caused by infection with the attenuated Mycobacterium bovis strain used in BCG.
4. Disseminated BCG infection — Correct
- A rare but serious complication.
- It may occur particularly in patients with underlying immunodeficiency.
- It represents widespread infection with the BCG strain.