NON- HODGKIN’S LYMPHOMA

• Non- Hodgkin’s lymphoma (NHL) is a monoclonal proliferation of lymphoid cells.

 Etiology-

• Small lymphocytic lymphoma
• Lymphoblastic lymphoma
• Follicular lymphoma
• Burkitt’s lymphoma
• Virus- HIV virus, EBV
• Bacteria- H.pylori

Classification-

1. Low grade-

• Small, follicular, small cleaved cells.

2. Intermediate grade-

• Follicular, large
• Diffuse, small cleaved cell
• Diffuse mixed small & large cell.
• Diffuse large cell

3. High grade

• Large cell immunoblastic
• Lymphoblastic
• Burkitt’s or non- Burkitt’s lymphoma

Clinical features-

• Lymphadenopathy
• Weight loss, sweat & fever.
• Hepatosplenomegaly
• Extranodal disease (common in NHL)

Investigations-

• Immunophenotyping of surface antigens
• Liver function test with LDH
• Biopsy

Treatment-

1. Low grade NHL-

• Chemotherapy with COPP (cyclophosphamide, oncovin, procarbazine, prednisolone) or ABVD with or without rituximab is the treatment of choice.

2. High grade NHL-

• Most common form, diffuse large B- cell NHL to COPP.
• Radiotherapy