Non Hodgkin Lymphoma

Non Hodgkin Lymphoma


NON- HODGKIN’S LYMPHOMA

  • Non- Hodgkin’s lymphoma (NHL) is a monoclonal proliferation of lymphoid cells.

Etiology-

  • lymphocytic lymphoma
  • Lymphoblastic lymphoma
  • Follicular lymphoma
  • Burkitt’s lymphoma
  • Virus- HIV virus, EBV
  • Bacteria- H.pylori

Classification-

1. Low grade-

  • , follicular, small cleaved cells.

2. Intermediate grade-

  • Follicular, large
  • Diffuse, cleaved cell
  • Diffuse mixed & large cell.
  • Diffuse large cell

3. High grade

  • Large cell immunoblastic
  • Lymphoblastic
  • Burkitt’s or non- Burkitt’s lymphoma

Clinical features-

  • Lymphadenopathy
  • Weight loss, sweat & fever.
  • Hepatosplenomegaly
  • Extranodal disease (common in NHL)

Investigations-

  • Immunophenotyping of surface antigens
  • Liver function test with LDH
  • Biopsy

Treatment-

1. Low grade NHL-

  • Chemotherapy with COPP (cyclophosphamide, oncovin, procarbazine, prednisolone) or ABVD with or without rituximab is the treatment of choice.

2. High grade NHL-

  • Most common form, diffuse large B- cell NHL to COPP.
  • Radiotherapy

Exam Important

Classification-

1. Low grade-

  • , follicular, cleaved cells.

2. Intermediate grade-

  • Follicular, large
  • Diffuse, cleaved cell
  • Diffuse mixed & large cell.
  • Diffuse large cell

3. High grade

  • Large cell immunoblastic
  • Lymphoblastic
  • Burkitt’s or non- Burkitt’s lymphoma

Clinical features-

  • Lymphadenopathy
  • Weight loss, sweat & fever.
  • Hepatosplenomegaly

Treatment-

1. Low grade NHL-

  • Chemotherapy with COPP (cyclophosphamide, oncovin, procarbazine, prednisolone) or ABVD with or without rituximab is the treatment of choice.

2. High grade NHL-

  • Most common form, diffuse large B- cell NHL to COPP.
  • Radiotherapy
Don’t Forget to Solve all the previous Year Question asked on Non Hodgkin Lymphoma

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