Question
GPCR that does not act through opening of potassium channels is?
A. Muscarinic M2 receptor
B. Dopamine D2 receptor
C. Serotonin 5 HT1 receptor
D. Angiotensin 1 receptor
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Correct Answer » D Explanation |
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Ans. D. Angiotensin 1 receptor
* Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GIRK ion channels.
* Activation of the IKACh channels begins with release of acetylcholine (ACh) from the vagus nerve onto pacemaker cells in the heart.
* ACh binds to the M2 muscarinic acetylcholine receptors, which interact with G proteins.