ANTIMETABOLITES
ANTIMETABOLITES USED IN CANCER CHEMOTHERAPY
- Compounds with structural similarity to precursors of purines or pyrimidines (Synthetic Nucleotides), or compounds that interfere with purine or pyrimidine synthesis are called antimetabolites.
| Compound | Use | Nucleoside analogue |
| Bromodeoxyuridinea | Study cell proliferation | Thymidine analogue |
| Allopurinal | Anti gout drug | Hypoxanthine analogue |
| Azathiopine | Immunosuppressant | Purine analogue |
- Mycophenolic Acid-Potent Reversible uncompetitive inhibitor of IMP Dehydrogenase
- S-Fluorouracil (5FU) inhibits thymidylatesynthetase
- Allopurinol is a powerful inhibitor of xanthine oxidase
- Allopurinol is an analog of hypoxanthine.
Exam Important
- Synthetic nucleotide used in the treatment of AIDS- Zidovudine.
- Synthetic nucleotide used in the treatment of Gout-Allopurinol
- Synthetic nucleotide used to suppress immunologic rejection during organ transplantation-Azathioprine.
- Allopurinol is a powerful inhibitor of xanthine oxidase.
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