ANTIMETABOLITES

ANTIMETABOLITES


ANTIMETABOLITES USED IN CANCER CHEMOTHERAPY

  • Compounds with structural similarity to precursors of purines or pyrimidines (Synthetic Nucleotides), or compounds that interfere with purine or pyrimidine synthesis are called antimetabolites. 
Compound Use Nucleoside analogue
Bromodeoxyuridinea Study cell proliferation Thymidine analogue
Allopurinal Anti gout drug Hypoxanthine analogue
Azathiopine Immunosuppressant Purine analogue
  • Mycophenolic Acid-Potent Reversible uncompetitive inhibitor of IMP Dehydrogenase
  • S-Fluorouracil (5FU) inhibits thymidylatesynthetase
  • Allopurinol is a powerful inhibitor of xanthine oxidase
  • Allopurinol is an analog of hypoxanthine.

Exam Important

  • Synthetic nucleotide used in the treatment of AIDS- Zidovudine.
  • Synthetic nucleotide used in the treatment of Gout-Allopurinol
  • Synthetic nucleotide used to suppress immunologic rejection during organ transplantation-Azathioprine.
  • Allopurinol is a powerful inhibitor of xanthine oxidase.
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