Site icon New

Fatty liver

amit18289

Fatty liver

3
Q. 1 Accumulation and deposition of which of the following result in the fatty liver:
 A Triglycerides
 B

Lipoproteins
 C

LDL
 D

VLDL
Q. 2

All of the following statements about Non Alcoholic Fatty Liver disease are true, except:

 A

Common in Diabetics
 B

Clofibrate provides effective treatment
 C

Commonest cause of cryptogenic cirihosis
 D

Associated with elevated transminases
Q. 3

Fatty liver is due to accumulation of ‑

 A

Triglycerides
 B

LDL
 C

Lipoprotein a
 D

VLDL
Q. 1

Accumulation and deposition of which of the following result in the fatty liver:

 A

Triglycerides
 B

Lipoproteins
 C

LDL
 D

VLDL
Ans. A
Explanation:

Fatty liver refers to the deposition of excess triglycerides in the liver cells.

Causes of fatty liver are:
  • Increased mobilization of nonesterified fatty acids from adipose tissue.
  • Increased synthesis of fatty acid from glucose.
  • Decreased secretion of VLDL.
  • Decreased rate of oxidation of fat by hepatic cells.

 

Q. 2

All of the following statements about Non Alcoholic Fatty Liver disease are true, except:

 A

Common in Diabetics
 B

Clofibrate provides effective treatment
 C

Commonest cause of cryptogenic cirihosis
 D

Associated with elevated transminases
Ans.
B
Explanation:

Answer is B (Clofibrate provides effective treatment):

Non Alcoholic fatty Liver Disease (NAFLD) is common in Diabetics Commonest Associations of NAFLD / NASH (Robbins)

  • Obesity
  • Dyslipidemia
  • Hyperinsulinemia (Insulin resistance is a charachteristic.feature2)
  • Diabetes

NAFLD is believed to be the commonest cause of cryptogenic cirrhosis

NAFL is now considered the most common cause of ‘ctyptogenic cirrhosis’ – Robbins 7th/908 Spectrum of NAFLD

  • Simple steatosis (Early)
  • Steatohepatitis (NASH) : Non Alcoholic Steatohepatitis) (Intermediate)
  • Fibrosis and cirrhosis (Advanced)

NAFLD is associated with elevated transminases (transaminitis)

‘Most patients with NAFLD come to medical attention as a result of incidentally elevated liver enzymes’ – Harrison

  • ALT > AST
  • Aminotransferases are usually only mildly elevated 2 times normal
Q. 3 Fatty liver is due to accumulation of ‑
 A Triglycerides
 B

LDL
 C

Lipoprotein a
 D

VLDL
Ans.
A
Explanation:

Ans. is ‘a’ i.e., Triglycerides

Fatty change (Steatosis) :‑

  • The term steatosis (fatty change) describe abnormal accumlation of triglyceride within parenchymal cells.