Fatty liver
| A | Triglycerides | |
| B |
Lipoproteins |
|
| C |
LDL |
|
| D |
VLDL |
Accumulation and deposition of which of the following result in the fatty liver:
| A |
Triglycerides |
|
| B |
Lipoproteins |
|
| C |
LDL |
|
| D |
VLDL |
Fatty liver refers to the deposition of excess triglycerides in the liver cells.
- Increased mobilization of nonesterified fatty acids from adipose tissue.
- Increased synthesis of fatty acid from glucose.
- Decreased secretion of VLDL.
- Decreased rate of oxidation of fat by hepatic cells.
All of the following statements about Non Alcoholic Fatty Liver disease are true, except:
| A |
Common in Diabetics |
|
| B |
Clofibrate provides effective treatment |
|
| C |
Commonest cause of cryptogenic cirihosis |
|
| D |
Associated with elevated transminases |
Answer is B (Clofibrate provides effective treatment):
Non Alcoholic fatty Liver Disease (NAFLD) is common in Diabetics Commonest Associations of NAFLD / NASH (Robbins)
- Obesity
- Dyslipidemia
- Hyperinsulinemia (Insulin resistance is a charachteristic.feature2)
- Diabetes
NAFLD is believed to be the commonest cause of cryptogenic cirrhosis
NAFL is now considered the most common cause of ‘ctyptogenic cirrhosis’ – Robbins 7th/908 Spectrum of NAFLD
- Simple steatosis (Early)
- Steatohepatitis (NASH) : Non Alcoholic Steatohepatitis) (Intermediate)
- Fibrosis and cirrhosis (Advanced)
NAFLD is associated with elevated transminases (transaminitis)
‘Most patients with NAFLD come to medical attention as a result of incidentally elevated liver enzymes’ – Harrison
- ALT > AST
- Aminotransferases are usually only mildly elevated 2 times normal
| A | Triglycerides | |
| B |
LDL |
|
| C |
Lipoprotein a |
|
| D |
VLDL |
Ans. is ‘a’ i.e., Triglycerides
Fatty change (Steatosis) :‑
- The term steatosis (fatty change) describe abnormal accumlation of triglyceride within parenchymal cells.
