MCQ – 23462

Correct Answer » B Explanation

Correct Answer: B. Alzheimer’s disease

Detailed Explanation:

Clinical reasoning for the correct answer:
– Alzheimer’s disease is a progressive neurodegenerative disorder causing irreversible dementia.
– It is characterized by amyloid plaques and neurofibrillary tangles leading to irreversible neuronal loss.
– There is no current cure or reversal, only symptomatic management.

Why Option A is incorrect:
– Toxic dementia is caused by reversible factors such as drug intoxication or metabolic disturbances.
– Removing the toxin or treating the underlying cause often resolves or improves cognitive impairment.
– Examples include alcohol-related dementia and heavy metal poisoning.

Why Option C is incorrect:
– Multi-infarct dementia results from multiple ischemic strokes affecting cognition.
– While cognitive decline can be chronic, preventing further strokes and managing risk factors may partially stabilize or improve symptoms.
– Some improvement possible with rehabilitation.

Why Option D is incorrect:
– Pick’s disease (frontotemporal dementia) is a progressive and irreversible neurodegenerative disorder like Alzheimer’s disease.
– However, Alzheimer’s disease is a more common and prototypical irreversible dementia.
– Pick’s disease is irreversible but less common than Alzheimer’s; if a single answer must be selected, Alzheimer’s disease remains the best choice due to prevalence and classical teaching.

Note: Both Alzheimer’s disease and Pick’s disease are irreversible, but Alzheimer’s disease is often considered the prototypical irreversible dementia in clinical MCQs.