Question
Which of the following is represented in the below figure by drug X?
| A. |
Epsilon Amino Caproic acid
|
| B. |
Clopidogrel
|
| C. |
Tenecteplase
|
| D. |
Aspirin
|
Show Answer
|
Correct Answer » A
Explanation
|
|
The diagram shows:
Plasminogen → Plasmin → Fibrin degradation products
- Streptokinase promotes conversion of plasminogen to plasmin.
- Plasmin breaks down fibrin and produces fibrin degradation products, resulting in fibrinolysis.
- PAI-1 (plasminogen activator inhibitor-1) inhibits plasminogen activation.
- α₂-antiplasmin inhibits plasmin.
Drug X = Epsilon-aminocaproic acid, an antifibrinolytic drug that inhibits the fibrinolytic process by interfering with the interaction of plasminogen/plasmin with fibrin.
Why the other options are incorrect
B. Clopidogrel
- Antiplatelet drug.
- It irreversibly inhibits the platelet P2Y12 adenosine diphosphate (ADP) receptor.
- It does not inhibit fibrinolysis.
C. Tenecteplase
- Tenecteplase is a modified recombinant tissue plasminogen activator (tPA).
- It promotes conversion of plasminogen → plasmin, thereby causing fibrinolysis.
- Thus, it has an effect opposite to epsilon-aminocaproic acid.
D. Aspirin
- Antiplatelet drug.
- Irreversibly inhibits cyclooxygenase-1 (COX-1) in platelets, decreasing thromboxane A₂ synthesis and platelet aggregation.
- It does not directly inhibit fibrinolysis.
