Question
Which among the following will activate carbamoyl phosphate synthetase I:
| A. | Alanine |
| B. |
N-acetyl glutamate |
| C. |
Ornithine |
| D. |
None |
Show Answer
|
Correct Answer � B Explanation |
 |
Carbamoyl phosphate synthase-I (CPS-I), a mitochondrial enzyme, catalyzes the formation of carbamoyl phosphate by condensation of CO2 and ammonia and ATP
Two molecules of ATP are required for the reaction.
CPS-I is the rate-limiting enzyme of the urea cycle.
It is an allosteric enzyme and allosterically activated by N-acetyl glutamate.