Question
Which among the following will activate carbamoyl phosphate synthetase I:
| A. |
Alanine
|
| B. |
N-acetyl glutamate
|
| C. |
Ornithine
|
| D. |
None
|
Show Answer
|
Correct Answer � B
Explanation
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|
Carbamoyl phosphate synthase-I (CPS-I), a mitochondrial enzyme, catalyzes the formation of carbamoyl phosphate by condensation of CO2 and ammonia and ATP
Two molecules of ATP are required for the reaction.
CPS-I is the rate-limiting enzyme of the urea cycle.
It is an allosteric enzyme and allosterically activated by N-acetyl glutamate.
