Methyl directed DNA repair
Mismatch repair basics
- Mismatch detected in newly synthesised DNA
- New DNA is cut & mismatched nucleotide & its neighbours are removed
- Missing patch is replaced with correct nucleotides by DNA polymerase
- DNA ligase seals the gap in DNA backbone
Methyl directed repair-prokaryotes
Methyl directed repair-Eukaryotes
→ MSH2, MLH1, MSH3 and MSH6
→ Hereditary Non-Polyposis Ca Colon [HNPCC]