Methyl directed DNA repair

Methyl directed DNA repair

Mismatch repair basics

  • Mismatch detected in newly synthesised DNA
  • New DNA is cut & mismatched nucleotide & its neighbours are removed
  • Missing patch is replaced with correct nucleotides by DNA polymerase
  • DNA ligase seals the gap in DNA backbone

Methyl directed repair-prokaryotes

Methyl directed repair-Eukaryotes

→ MSH2, MLH1, MSH3 and MSH6

→ Hereditary Non-Polyposis Ca Colon [HNPCC]

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