MINIMAL ALVEOLAR CONCENTRATION (MAC)
| A | Sevoflurane is more potent than isoflurane | |
| B |
Sevoflurane is less cardiodepressant than isoflurane |
|
| C |
Desflurane has lower blood-gas partition coefficient than sevoflurane |
|
| D |
Sevoflurane has a higher MAC than isoflurane |
Exception of Meyer overton rule are A/E
| A |
Nonanaesthetics |
|
| B |
Nonimmobilizer |
|
| C |
Cut off effect |
|
| D |
Hydrophobic site |
NOT TRUE regarding sevoflurane
| A |
MAC is higher than isoflurane |
|
| B |
Blood gas coefficient is higher than desflurane |
|
| C |
Potency more than isoflurane |
|
| D |
Sevoflurane is less cardio depressant than isoflurane |
Which of the following statements about inhalation anesthetic agents is wrong?
| A |
Sevoflurane is more potent than isoflurane |
|
| B |
Sevoflurane is less cardiodepressant than isoflurane |
|
| C |
Desflurane has lower blood-gas partition coefficient than sevoflurane |
|
| D |
Sevoflurane has a higher MAC than isoflurane |
Sevoflurane is less potent than isoflurane as it lacks coronary vasodilating properties.
Ref: Handbook of Clinical Anesthesia By Barash, Cullen, Stoelting , 5th Edition, Page 216; Handbook of Clinical Anesthesia By Paul G. Barash, Bruce F. Cullen, Robert K. Stoelting, M. Christine Stock, 6th Edition, Page 231
Exception of Meyer overton rule are A/E
| A |
Nonanaesthetics |
|
| B |
Nonimmobilizer |
|
| C |
Cut off effect |
|
| D |
Hydrophobic site |
D i.e. Hydrophobic site
Non anesthetics/ nonimmobilizers, cut off effect convulsant gases, isomers, hydrophilic site and critical volume expanism hypothesis provide exceptions to the meyer – overton ruleQ.
NOT TRUE regarding sevoflurane
| A |
MAC is higher than isoflurane |
|
| B |
Blood gas coefficient is higher than desflurane |
|
| C |
Potency more than isoflurane |
|
| D |
Sevoflurane is less cardio depressant than isoflurane |
D i.e., Sevoflurane is less cardio depressant than isoflurane
Sevoflurane is an inhalational agent of choice for induction of anaesthesia in pediatric patients and adults, because of rapid onset of action & nonpengency
Desflurane & isoflurane are more pungent and are associated with more coughing breath holding & laryngeal spasm during inhalational induction, so not used as the first choice.
Methoxyflurane is highly nephrotoxic, so not preferred.
Sevoflurane is not recommended in the closed-circuit because there is a chance of production of a toxic metabolic product compound A, Q (an olefin) in closed circuit.
– Unlike isoflurane & desflurane, both of which lead to tachycardia, sevoflurane has minimal effect on heart rate.
Sevoflurane can cause direct myocardial depression (via calcium channels) and produce dose-dependent depression of cardiac output, & reduction in systemic vascular resistance similar to that seen in isoflurane