MINIMAL ALVEOLAR CONCENTRATION (MAC)
Which of the following statements about inhalation anesthetic agents is wrong?
| A |
Sevoflurane is more potent than isoflurane |
|
| B |
Sevoflurane is less cardiodepressant than isoflurane |
|
| C |
Desflurane has lower blood-gas partition coefficient than sevoflurane |
|
| D |
Sevoflurane has a higher MAC than isoflurane |
Which of the following statements about inhalation anesthetic agents is wrong?
| A |
Sevoflurane is more potent than isoflurane |
|
| B |
Sevoflurane is less cardiodepressant than isoflurane |
|
| C |
Desflurane has lower blood-gas partition coefficient than sevoflurane |
|
| D |
Sevoflurane has a higher MAC than isoflurane |
Sevoflurane is less potent than isoflurane as it lacks coronary vasodilating properties.
Ref: Handbook of Clinical Anesthesia By Barash, Cullen, Stoelting , 5th Edition, Page 216; Handbook of Clinical Anesthesia By Paul G. Barash, Bruce F. Cullen, Robert K. Stoelting, M. Christine Stock, 6th Edition, Page 231
Exception of Meyer overton rule are A/E
| A |
Nonanaesthetics |
|
| B |
Nonimmobilizer |
|
| C |
Cut off effect |
|
| D |
Hydrophobic site |
Exception of Meyer overton rule are A/E
| A |
Nonanaesthetics |
|
| B |
Nonimmobilizer |
|
| C |
Cut off effect |
|
| D |
Hydrophobic site |
D i.e. Hydrophobic site
Non anesthetics/ nonimmobilizers, cut off effect convulsant gases, isomers, hydrophilic site and critical volume expanism hypothesis provide exceptions to the meyer – overton ruleQ.
NOT TRUE regarding sevoflurane
| A |
MAC is higher than isoflurane |
|
| B |
Blood gas coefficient is higher than desflurane |
|
| C |
Potency more than cardio depressant than isoflurane |
|
| D |
Sevoflurane is less cardio depressant than isoflurane |
NOT TRUE regarding sevoflurane
| A |
MAC is higher than isoflurane |
|
| B |
Blood gas coefficient is higher than desflurane |
|
| C |
Potency more than cardio depressant than isoflurane |
|
| D |
Sevoflurane is less cardio depressant than isoflurane |
D i.e., Sevoflurane is less cardiodepressant than isoflurane
Sevoflurane is inhalational agent of choice for inductioin of anesthesia in pediatric patients and adults, because of rapid onset of action & nonpengency Q
Desflurane & isoflurane are more pungent and are associated with more coughing breath holding & laryngeal spasm during inhalational inudction, so not used as first choiceQ.
Methoryflurane is highly nephrotoxic, so not preferred.
Sevoflurane is not recommended in closed circuit because there is chance of production of a toxic metabolic product compound A, Q (an olefin) in closed circuit.
– Unlike isoflurane & desflurane, both of which lead to tachycaridia, sevoflurane has minimal effect on heart rate.
Sevoflurane can cause direct myocardial depression (via calcium channels) and produce dose dependent depression of cardiac output, & reduction in systemic vascular resistance similar to that seen in isoflurane
