Diczfalusy’s concept

 Estrogen → Estrogen cannot be synthesized by placenta alone as it cannot utilize C21 steroid due to lack of enzyme 17 alpha hydroxylase. → Hence conversion of C21 to C19 is not possible (Diczfalusy’s concept). → Fetal adrenal gland produces DHEA-S which is utilized by placental enzymes to synthesize estradiol & estriol. → M/C […]