Question
The risk of endometrial carcinoma is highest with the following histological pattern .
A. Simple hyperplasia with atypia.
B. Simple hyperplasia without atypia.
C. Complex hyperplasia with atypia.
D. Complex hyperplasia without atypia.
Show Answer
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Correct Answer » C Explanation |
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This histological pattern is of endometrial hyperplasia
Ans. C: Complex hyperplasia with atypia
Simple hyperplasia progresses to cancer in 10-20% whereas atypical hyperplasia is a precursor of cancer in 60-70% of cases.
Classification
- Most endometrial cancers are carcinomas (usually adenocarcinomas
Endometrial carcinomas can be classified into two pathogenetic groups:
- Type I: These cancers occur most commonly in pre- and peri-menopausal women, often with a history of unopposed estrogen exposure and/or endometrial hyperplasia. They are often minimally invasive into the underlying uterine wall, are of the low-grade endometrioid type, and carry a good prognosis.
- Type II: These cancers occur in older, post-menopausal women, and are not associated with increased exposure to estrogen. They are typically of the high-grade endometrioid, papillary serous or clear cell types, and carry a generally poor prognosi