Question
The blood smear of a patient shows the presance of following as marked by a black arrow in the picture below.Most likely the medical condition involve is?
A. Megaloblastic anaemia.
B. Liver diseases.
C. G6PD deficiency.
D. None of the above.
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Correct Answer » A Explanation |
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Ans: A. Megaloblastic Anemia
Arrow point in the image shows Howell Jolly Body
Howell-Jelly Body
- They are histopathological findings of basophilic nuclear remnants(smooth,round remnants) (clusters of DNA) in circulating erythrocytes.
- Usually, only one per cell is seen but, occasionally, there may be more than one in some cases.
- During maturation in the bone marrow late erythroblasts normally expel their nuclei, but in some cases a small portion of DNA remains.
- Its presence usually signifies a damaged or absent spleen because a healthy spleen would normally filter this type of red blood cell.
- Howell–Jolly bodies are also seen in: amyloidosis, severe hemolytic anemia, megaloblastic anemia, hereditary spherocytosis, heterotaxy with asplenia and myelodysplastic syndrome (MDS).
- Also can be seen in premature infants.