Question
These cells are characteristic of
A. Tetanus
B. Rabies
C. Polio
D. AIDS
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Correct Answer » B Explanation |
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Negri bodies
Ans. B: Rabies
Since first described by Negri in 1903, the presence of the Negri bodies are practically pathognomic for rabies and are an important diagnostic finding.
Negri bodies are discrete, intracytoplasmic, deeply eosinophilic inclusions that measure several microns in diameter. In about 75% of cases of rabies these can be seen on hematoxylin and eosin stained sections.
They occur in neurons of the brain stem, particularly those in the hippocampus, and in the Purkinje cells of the cerebellum. Ultrastructural studies have shown that Negri body consists of a mass of nucleocapsids surrounded by viral particles budding from intracytoplasmic membranes.