Question
A patient presented with a parotid swelling after undergoing Radiation therapy.Histopathological examination shows the following features.What can be the most probable diagnosis?
A. Mucoepidermoid Carcinoma
B. Adenoid Cystic Carcinoma
C. Warthin’s Tumor
D. Pleomorphic Adenoma
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Correct Answer » A Explanation |
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Ans:A. Mucoepidermoid Carcinoma.
Image shows:This image shows a low grade component of this high grade neoplasm containing glands lined by goblet cells, squamous cells and intermediate cells as well as an oval squamous cell nest in the center.
Mucoepidermoid Carcinoma
- It is the most common malignant salivary gland tumour (both in the major and minor glands).
- The parotid gland amongst the major salivary glands and the minor salivary glands in the palate are the most common sites.
- Common age group affected is 30-60 years but it is also the most common malignant salivary gland tumour affecting children and adolescents.
- It is the most common example of radiation-induced malignant tumour, especially therapeutic radiation.
MORPHOLOGIC FEATURES.
- Grossly, the tumour is usually circumscribed but not encapsulated. It varies in size from 1 to 4 cm.
- Microscopically, the tumour is classified into low, intermediate and high grade depending upon the degree of differentiation and tumour invasiveness.
- The tumour is composed of combination of 4 types of cells: mucin producing, squamous, intermediate and clear cells.
- Well differentiated tumours have predominance of mucinous cells, while poorly differentiated have more solid and infiltrative pattern.