Question
True regarding paracetamol intoxication in children?
A. Large single dose of 5mg/kg is hepatotoxic
B. Acetylcysteine is specific antidote
C. Serum enzymes are raised to 1000 iu/1
D. Bilirubin can be raised within 24 hours
E. Acetylcysteine administration is beneficial even after 24 hours
Show Answer
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Correct Answer » B:C:D:E
Explanation
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Ans. B, C, D & E
Minimum toxic doses of acetaminophen in children for a single ingestion, posing significant risk of severe hepatotoxicty is 150 mg/kg.
N-acetylcystine (NAC) is a specific, safe and effective antidote as it replenishes glutathione stores.
Toxicity is defined as serum AST or ALT concentrations greater than 1000 IU/L.
Even delayed therapy may be beneficial.
Therefore, treatment should be considered even if 24 hours or more has elapsed since the last dose of acetaminophen was given.
