Question
Mechanism of action of vincristine includes?
A. Inhibition of protein, DNA & RNA synthesis
B. Acts in metaphase and causing arrest
C. Inhibition of microtubule formation
D. Acts as cell cycle specific agents
E. Enhances polymerization of tubulin
Show Answer
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Correct Answer » A:B:C:D
Explanation
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Ans. A, b, C & D
The synthesis of all the classes of DNA discriminated by density gradient centrifugation is inhibited by vincristine.
Because RNA and protein synthesis in human Leucocytes were closely linked it could not be determined which process was inhibited first by the alkaloid.
