Question
True regarding pulmonary alveolar proteinosis is/are?
A. Antibodies to GM-CSF
B. Deposition of PAS positive material in lung alveoli
C. Hemorrhagic material deposition in bronchioalveolar lavage
D. Milky material deposition in bronchioalveolar lavage
E. More common in elderly
Show Answer
|
Correct Answer » A:B:D
Explanation
|
|
Ans. A, B & D
In adults, the most common cause of PAP is an autoimmunity to granulocyte-macrophage colony stimulating factor (GM-CSF). This leads to granulocyte-macrophage colony-stimulating factor (GM-CSF) antibiotics and GM-CSF deficiency.
Light microscopy of the lung parenchymal tissue shows alveoli filled with a granular PAS base-reactive and diastase resistant eosinophilic material.
Bronchoalveolar lavage fluid appearance milky.
“Papanicolaou staining may reveal green and orange globules that are diagnostic for PAP.
Patients are typically aged 20-50 years at presentation.
