Question
True regarding pulmonary alveolar proteinosis is/are?
A. Antibodies to GM-CSF
B. Deposition of PAS positive material in lung alveoli
C. Hemorrhagic material deposition in bronchioalveolar lavage
D. Milky material deposition in bronchioalveolar lavage
E. More common in elderly
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Correct Answer » A:B:D Explanation |
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Ans. A, B & D
In adults, the most common cause of PAP is an autoimmunity to granulocyte-macrophage colony stimulating factor (GM-CSF). This leads to granulocyte-macrophage colony-stimulating factor (GM-CSF) antibiotics and GM-CSF deficiency.
Light microscopy of the lung parenchymal tissue shows alveoli filled with a granular PAS base-reactive and diastase resistant eosinophilic material.
Bronchoalveolar lavage fluid appearance milky.
“Papanicolaou staining may reveal green and orange globules that are diagnostic for PAP.
Patients are typically aged 20-50 years at presentation.