Question
True regarding acute graft rejection is?
A. T-cell mediated
B. Preformed anti-HLA antibodies mediated
C. Strong predictor for chronic renal transplant rejection
D. Can be reversed by increasing the dose of immunosuppressives
E. Poor graft survival
Show Answer
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Correct Answer » A:B:C:D:E
Explanation
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Ans. A, B, C, D & E
Acute cellular rejection affects greater than a third of lung transplant recipients.
All reactive T lymphocytes, responding directly or indirectly to donor antigen, constitute the basis of lung allograft rejection.
Recent evidence supports a more complex immune response to the allograft with involvement of humoral mechanisms, characterized by circulating antibody to donor HLA and specific patterns of lung injury, occurring in parallel with T cell-based rejection.
