Question
Loss of foot process is classical in case of?
A. Membranous glomerulitis
B. Segmental glomerulosclerosis
C. IgA nephropathy
D. Diabetic nephropathy
Show Answer
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Correct Answer » B
Explanation
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Ans: B. Segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a condition in which there is sclerosis and hyalinosis of some glomeruli and portions of their tuft (less than 50% in a tissue section), while the other glomeruli are normal by light microscopy i.e. involvement is focal and segmental.
In electron microscopy, diffuse loss of foot processes as seen in minimal change disease is evident but also, there are electron-dense deposits in the region of hyalinosis and sclerosis which are believed to be immune complexes.
