A 5 years old girl presented with lesion on the face for the last 3 months. A skin biopsy was performed and the findings are shown below. What is the diagnosis?
A. Squamous cell carcinoma
B. Squamous papilloma with central crater
C. Molluscum contagiosum
D. Herpes zoster
Ans: C. Molluscum contagiosum
(Ref: Robbins 9/e p1176; Fitzpatrick 6/e p2347)
- All findings are highly suggestive of Molluscum contagiosum, which is caused by the poxvirus.
- On microscopic examination, lesions show cuplike verrucous epidermal hyperplasia. The diagnostically specific structure is the molluscum body, which occurs as a large, ellipsoid, homogeneous, cytoplasmic inclusion in cells of the stratum granulosum and the stratum corneum.
- In H&E stain, these inclusions are eosinophilic in the blue-purple stratum granulosum and acquire a pale blue hue in the red stratum corneum.
- Numerous virions are present within molluscum bodies