Question
What is the main feature of chemotaxis as observed in white blood cells?
A. Increased random movement of neutrophils
B. Increased adhesiveness to intima
C. Increased phagocytosis
D. Unidirectional locomotion of neutrophils
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Correct Answer » D Explanation |
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Ans: D. Unidirectional locomotion of neutrophils
Chemotaxis is defined as a unidirectional movement of leukocytes up to a concentration gradient of chemotactic molecules. All granulocytes, monocytes and to a lesser extent lymphocytes respond to chemotactic stimuli with varying rates of speed.
Chemoattractants are exogenous or endogenous. Exogenous agents are bacterial products. Endogenous mediators are:
- Components of complement pathway C5a
- Products of lipoxygenase pathway LTB4
- Cytokines particularly those of chemokine families.