Question
Fluoroquinolone contraindicated in liver disease is
A. Levofloxacin
B. Pefloxacin
C. Ofloxacin
D. Lomefloxacin
Show Answer
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Correct Answer » B
Explanation
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Ans: B. Pefloxacin
Pefloxacin has longer t½: accumulates on repeated dosing achieving plasma concentrations twice as high as after a single dose.
Because of this, it is effective in many systemic infections as well.
The dose of pefloxacin needs to be reduced in liver disease, but not in renal insufficiency.
Ref: K. D. Tripathi 7th Edition. Page. 713
