Question
A patient was recently started on Fluphenazine. A few weeks later, he developed tremors, rigidity, bradykinesia, and excessive salivation. The first line of management for this patient is
A. Selegiline
B. Trihexyphenidyl
C. Pramipexole
D. Amantadine
Show Answer
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Correct Answer » B
Explanation
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Ans: B. Trihexyphenidyl
* Fluphenazine may block the effects of agents used to treat Parkinson’s disease such as levodopa/carbidopa.
* Trihexyphenidyl is an antispasmodic drug that exerts a direct inhibitory effect on the parasympathetic nervous system.
– It also has a relaxing effect on smooth muscle.
– It is indicated in all forms of Parkinsonism.
* Trihexyphenidyl works as an anticholinergic and is used for the treatment of tremors, spasms, stiffness, and weak muscle control seen in patients with Parkinson’s disease.
– It can also be used for the prevention or treatment of similar muscular conditions which are caused by certain central nervous system (CNS) drugs such as fluphenazine, haloperidol, chlorpromazine.
