Question
Which of the following anticancer drugs are competitive inhibitors of tyrosine kinase –
A. Imatinib and sunitinib
B. Letrozole
C. Bicalutamide
D. Fulvestrant
Show Answer
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Correct Answer » A
Explanation
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Ans. is ‘a’ i.e., Imatinib and sunitinib
Molecular targeted agents
Tyrosine kinase inhibitors
Competitive inhibitors → Imatinib, Nilotinib, Sunitinib, Dasatinib, Erlotinib, Gefitinib, Lapatinib, Sorafenib (Remember all end with ‘ nib’).
Monoclonal antibodies → Cetuximab, panitumumab.
HER2/neu (ERB B2) inhibitors Monoclonal antibody – Trastuzumab.
Targeted antibody → Gemtuzumab (anti CD-33), Rituximab (anti – CD20), Alemtuzumab (anti CD-52).
Vascular endothelial growth factor (VEGF) inhibitor → Monoclonal antibody – Bevacizumab.
Proteosome inhibitors → Bortezomib.
Histone deacetylase inhibitor → Vorinostat
DNA – methyltransferase inhibitor → 5-azacytidine, 2-deoxy-5 azacytidine
All – trans-retinoic acid.
Biological response modifier – Recombinant IL-2 (aldesleukin, denileukin)
