Question
Binding of Eukaryotic mRNA to Ribosomes is facilitated by
A. Capping
B. Poly-A tail
C. tRNA
D. Shine-Dalgarno sequence
Show Answer
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Correct Answer » A
Explanation
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Answer- A. Capping
* In E. coli mRNA, a leader sequence upstream of the first AUG codon, called the Shine-Dalgarno sequence (also known as the ribosomal binding site AGGAGG), interacts through complementary base pairing with the rRNA molecules that compose the ribosome.
* In eukaryotic initiation complex recognizes the 5′ cap of the eukaryotic mRNA, then tracks along the mRNA in the 5′ to 3′ direction until the AUG start codon is recognized. At this point, the 60S subunit binds to the complex of Met-tRNAi, mRNA, and the 40S subunit.
