Question
Match the following types of lymphoma with types of translocations
column A
A. Burkitt’s lymphoma
B. Mantle tumor
C. Marginal tumor
D. Follicular tumor
column B
1. t(11,14)
2. t(11,18)
3. t(8,14)
4. t(14,18)
A. a-1,b-2,c-3,d-4
B. A-2,b-1,c-4,d-3
C. A-2,b-3,c-1,d-4
D. a-3,b-1,c-2,d-4
Show Answer
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Correct Answer » D
Explanation
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Ans: D. a-3,b-1,c-2,d-4
* All types of Burkitt lymphoma are characterized by dysregulation of the c-Myc gene by one of three chromosomal translocations. The most common variant is t(8;14), which accounts for about 85%of cases.
* Mantle cell lymphoma (MCL) is a type of non-Hodgkin’s lymphoma (NHL), comprising about 6%, Specifically, the translocation is at t(11;14)(q13;q32).
* Extranodal marginal zone lymphomas are commonly associated with chromosomal abnormalities with translocations at t(11;18)(q21;q21), t(1;14)(p22;q32), t(3;14)(p12;q32), and trisomy 3 or 18.
* The chromosomal translocation t(14;18)(q32;q21) is characteristic of follicular lymphoma and a frequent abnormality in other types of non-Hodgkin lymphoma (NHL)
