Question
Match the following
A. anti jo1
B. anti topoisomerase
C. anti u1rnp
D. anti smith
1. systemic sclerosis
2. sle
3. anti synthetase
4. systemic sclerosis
5. dermatomyositis
A. a-2,b-3,c-1,d-4
B. a-3,b-2,c-5,d-1
C. a-2,b-5,c-4,d-3
D. a-5,b-3,c-2,d-4
Show Answer
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Correct Answer » B
Explanation
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Ans: B. a-3,b-2,c-5,d-1
Antisynthetase syndrome is a chronic autoimmune condition that affects the muscles and various other parts of the body.
The signs and symptoms of antisynthetase syndrome vary but may include:
* Fever
* Loss of appetite
* Weight loss
* Muscle inflammation (myositis)
* Inflammation of multiple joints (polyarthritis)
* Interstitial lung disease (ILD) causing shortness of breath, coughing, and/or dysphagia
* Mechanic’s hands (thickened skin of tips and margins of the fingers)
* Raynaud phenomenon
Myopathy occurs more often in patients with anti-Jo-1 or anti-PL-7; anti-Jo-1 is related to severe arthritis and “mechanic’s hand”, while anti-PL-12 with higher rates of Raynaud phenomenon; and anti-PL-7, anti-PL-12, anti-KS, and anti-OJ with cases of ILD.
